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SYRE Spyre Therapeutics, Inc.

Healthcare

95.51 -1.05 -1.09% Close 11/2
Since 2024-12-02 +249.2%
Open
97.11
High
98.00
Low
93.82
Prev close
96.56
Volume
749.3K
Amplitude
4.33%
P/B
7.7
52W 21.15 110.18

Is Spyre Therapeutics, Inc. a buy? Fundamentals and valuation first

As of 2026-10-30

Growth: Good, Momentum: Good, Risk / liquidity: Good; Valuation: Pricey, Quality: Weak.

Valuation Pricey Free-cash-flow yield is Average; Price / book is Expensive.
TTM P/E -49.52 N/A
Price / book 7.73 90th percentile Expensive
Free-cash-flow yield (%) -2.46 37th percentile Average
US Stock Backtest in Python: Price-to-Book Ratio StrategyQuality Factor Investing: A US Quality Value Backtest
Quality Weak ROE, TTM is Average; FCF margin, TTM is Lagging.
ROE, TTM (%) -16.25 28th percentile Average
Operating margin, TTM (%) -255.64 10th percentile Lagging
FCF margin, TTM (%) -231.08 9th percentile Lagging
Quality Factor Investing: A US Quality Value Backtest
Growth Good Revenue growth, TTM YoY is Top, but Diluted EPS growth, TTM YoY is Average.
Revenue growth, TTM YoY (%) — 99th percentile Top
Diluted EPS growth, TTM YoY (%) -12.95 49th percentile Average
Momentum Good 240-day return is Top; 60-day return is Good.
60-day return (%) -6.63 50th percentile Good
240-day return (%) 310.89 100th percentile Top
Momentum Trading Strategy: A 12-1 Momentum Backtest
Risk / liquidity Good 20-day dollar volume is Top, but 60-day annualized volatility is Average.
20-day dollar volume 111,797,064 88th percentile Top
60-day annualized volatility (%) 57.67 62th percentile Average
Factor Investing Explained: 10 Classic Factors in US Stocks

Spyre Therapeutics, Inc. (SYRE) today

1 quant signals active · As of 2026-10-30

Win rate and excess are historical post-trigger stats vs the market. Click a signal for its full definition and samples; history does not predict future results.

FinLab Studio

From Spyre Therapeutics, Inc. to every stock like it

AI finds several complementary traits of Spyre Therapeutics, Inc. across different dimensions, combines them into a multifactor strategy, and backtests it against the market.

Screen stocks like Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc. (SYRE) peers and tracking

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Spyre Therapeutics, Inc. (SYRE) quant signal backtests

Signals active now

Each active condition is tested against this stock’s own history and benchmarked versus the S&P 500.

Top-quintile 6-month momentum

Active · now 88.29%

The stock ranks in the top 20% of the liquid US common-stock universe by 126-day adjusted return.

Momentum Trading Strategy: A 12-1 Momentum Backtest
14 historical occurrences (since 2017-12-04)

Average forward return after Top-quintile 6-month momentum

20-day: Win 46.2%, Sample 13, Median -6.93%, Excess -5.57%, Beat mkt rate 46.2%

60-day: Win 30.8%, Sample 13, Median -12.81%, Excess -12.3%, Beat mkt rate 23.1%

120-day: Win 38.5%, Sample 13, Median -11.45%, Excess +4.95%, Beat mkt rate 30.8%

120 days after: historical avg +11.89%

20-day -3.93%
60-day -7.64%
120-day +11.89%
20-day
60-day
120-day
Win
46.2%
30.8%
38.5%
Sample
13
13
13
Median
-6.93%
-12.81%
-11.45%
Excess
-5.57%
-12.3%
+4.95%
Beat mkt rate
46.2%
23.1%
30.8%

Over 13 occurrences, 120-day forward avg gained 11.89%, beat the market by 4.95 pts; win rate 38.5%.

More history: Market-wide momentum baseline, Signals not active now

Market-wide momentum baseline

Across 99,493 liquid US common-stock samples, top-quintile 6-month momentum was followed by an average 60-trading-day return of +6.42%, a 58.4% positive-return rate, and +3.08 percentage points of average excess return versus the S&P 500.

Baseline: weekly samples since 2016 where a liquid US common stock ranked in the top quintile by 126-trading-day momentum. Forward return is 60 trading days; excess return is versus S&P 500 (^GSPC).

Signals not active now

Inactive signals still show the stock-specific historical forward-return distribution for context.

52-week adjusted-price high

Pending

Adjusted close first reaches a 252-trading-day high; repeated hits within 20 days count once.

11 times historically; 60-day forward avg +32.68%, win rate 72.7%, beating the market by +26.52 pts on average.

Filed revenue acceleration

Pending

TTM revenue growth is at least 10% and improved versus the prior filed quarter; event date is the SEC filing date.

EPS surprise beat

Pending

Reported EPS beat consensus estimate by at least 5%; event date is the earnings-surprise timestamp.

PEAD: Post-Earnings Announcement Drift Backtest

7 times historically; 60-day forward avg +0.77%, win rate 28.6%, beating the market by -0.72 pts on average.

Method and limits

  • Returns use us_price:adj_close, adjusted for splits and dividends where available.
  • Excess returns use world_index:^GSPC as the S&P 500 benchmark proxy.
  • Quarterly fundamentals are aligned to SEC filing dates before daily valuation studies.
  • The promoted universe starts from active NYSE/NASDAQ common stocks, then applies price and dollar-volume gates.
  • Snapshot-only tables such as analyst consensus, DCF, us_ratios, and us_key_metrics are intentionally excluded from historical evidence.
  • Overlapping event windows are descriptive distributions, not independent samples.

This page is for historical data analysis and education only. It is not investment advice. Backtests and historical return distributions do not predict future performance; evaluate risk independently before trading.